CBE645 Bioprocess Control And Instrumentation UITM Assignment Sample Malaysia

The CBE645 Bioprocess Control And Instrumentation course is a 4-credit course that covers the basics of process control and instrumentation. The course is designed for students who are interested in pursuing careers in the field of process control and/or instrumentation. The course covers topics such as process control fundamentals, process instrumentation, process control systems, and process optimization.

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Here, we will provide some assignment outlines. These are:

Assignment Outline 1: Describe and grasp the principle of various instruments used in the chemical and bioprocess industry.

The chemical and bioprocess industry relies on various instruments to measure, control, and monitor different process variables. Some of the commonly used instruments are:

  1. pH meter: A pH meter is used to measure the acidity or alkalinity of a solution. It works on the principle of measuring the voltage difference between a pH electrode and a reference electrode.
  2. Spectrophotometer: A spectrophotometer is used to measure the intensity of light absorbed by a sample. It works on the principle of measuring the amount of light absorbed by a sample at different wavelengths.
  3. Gas chromatograph: A gas chromatograph is used to separate and analyze different components of a gas mixture. It works on the principle of separating the components based on their different affinities for a stationary phase and a mobile phase.
  4. Mass spectrometer: A mass spectrometer is used to identify and quantify different components of a sample based on their molecular weight. It works on the principle of ionizing the sample molecules and separating them based on their mass-to-charge ratio.
  5. Thermocouple: A thermocouple is used to measure temperature. It works on the principle of measuring the voltage difference between two different metals that are joined at two different temperatures.
  6. Pressure gauge: A pressure gauge is used to measure the pressure of a fluid or gas. It works on the principle of measuring the force applied by the fluid or gas on a sensing element.
  7. Flowmeter: A flowmeter is used to measure the flow rate of a fluid. It works on the principle of measuring the velocity or volume of the fluid passing through a sensor.
  8. Conductivity meter: A conductivity meter is used to measure the conductivity of a solution. It works on the principle of measuring the current flow through the solution between two electrodes.

These instruments are essential for the smooth and efficient operation of chemical and bioprocess industries. They help in ensuring the quality and consistency of the products, optimizing the processes, and maintaining the safety of the operations.

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Assignment Outline 2: Select the appropriate system for a given chemical process in the process industry generally and bioprocess industry specifically.

The selection of an appropriate system for a chemical or bioprocess depends on various factors such as the type of process, the scale of operation, the desired product, the required level of purity, the operating conditions, and the cost-effectiveness.

In the process industry generally, some commonly used systems are:

  1. Batch Processing: It is suitable for small-scale production, where a fixed quantity of material is processed at a time. It is widely used in the pharmaceuticals, food, and specialty chemicals industries.
  2. Continuous Processing: It is used for large-scale production of chemicals, petrochemicals, and refining industries. The process runs continuously, with a steady supply of raw materials and a constant output of the final product.
  3. Semi-Batch Processing: It is a hybrid of batch and continuous processing. It is suitable for processes that require periodic additions of materials or adjustments to the operating conditions. It is commonly used in the production of polymers, resins, and specialty chemicals.

In the bioprocess industry specifically, the selection of an appropriate system depends on the type of organism used for the process, the desired product, the scale of operation, and the operating conditions. Some commonly used systems are:

  1. Batch Fermentation: It is suitable for the small-scale production of biologics, enzymes, and vaccines. It involves the inoculation of a fixed quantity of microorganisms into a batch of nutrient medium, which is then allowed to grow and produce the desired product.
  2. Continuous Fermentation: It is used for large-scale production of biofuels, biopolymers, and amino acids. It involves the continuous supply of nutrient medium and microorganisms, with a constant output of the desired product.
  3. Fed-Batch Fermentation: It is a hybrid of batch and continuous fermentation. It is suitable for processes that require periodic additions of nutrients or adjustments to the operating conditions. It is commonly used in the production of antibiotics, insulin, and recombinant proteins.

Assignment Outline 3: Design the control system with different mode of feeding the bioreactor which is applicable to bioprocess industry.

A bioreactor control system is a critical component in the bioprocess industry. It is responsible for monitoring and regulating the different parameters that affect the growth and metabolism of the microorganisms in the bioreactor. One of the most important parameters that the control system needs to manage is the feeding of the bioreactor. Here are three different modes of feeding the bioreactor that are commonly used in the bioprocess industry:

  1. Batch Feeding: In this mode of feeding, a fixed amount of nutrients is added to the bioreactor at the beginning of the process, and no additional nutrients are added until the end of the process. This is a simple and straightforward method, but it is not suitable for processes that require continuous feeding.
  2. Fed-Batch Feeding: In this mode of feeding, a certain amount of nutrients is added to the bioreactor at specific intervals. The intervals and the number of nutrients added can be adjusted based on the growth rate of the microorganisms and the metabolic activity. This method allows for better control of the process and is suitable for processes that require periodic feeding.
  3. Continuous Feeding: In this mode of feeding, a constant flow of nutrients is added to the bioreactor at a steady rate. This method is suitable for processes that require a constant supply of nutrients and continuous growth and metabolism of microorganisms.

To design a control system that can manage these different modes of feeding, the following components are necessary:

  1. Sensors: The control system needs to have sensors that can measure the different parameters in the bioreactor, such as pH, temperature, dissolved oxygen, and nutrient levels.
  2. Actuators: The control system needs to have actuators that can adjust the feeding rate based on the readings from the sensors.
  3. Control Algorithm: The control system needs to have a control algorithm that can adjust the feeding rate based on the target values and the feedback from the sensors. The algorithm should be able to switch between the different feeding modes based on the process requirements.
  4. User Interface: The control system needs to have a user interface that allows the operator to set the target values and adjust the parameters of the control algorithm.

By incorporating these components, a control system can be designed that is capable of managing the different modes of feeding in a bioreactor. This will allow for better control of the bioprocess, resulting in higher yields and better-quality products.

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