Today a 25-year-old male presented to the pharmacy and expressed concern to the pharmacist about the frequency: Pharmacology Assignment, UKM, Malaysia

Today a 25-year-old male presented to the pharmacy and expressed concern to the pharmacist about the frequency of one of his medication prescriptions. He has recently been prescribed the antibiotic amoxicillin for an upper respiratory tract infection.

The antibiotic needs to be taken daily 3 times per day, and he is having trouble remembering to take it. He asks the pharmacist why the antibiotic must be taken multiple times per day. Based on the pharmacokinetics parameters of amoxicillin, what factor would be the most involved in the frequency of dosing?

A 3-year-old child is brought to the hospital with a complaint of fever, cough, difficulty in breathing, and chest pain. On examination, he is found to be dull, but irritable with a fast pulse (118/min), rapid breathing (RR 55/min), the indrawing of the lower chest during inspiration, wheezing, crepitations, and mild dehydration.

Body temperature is 40° C. The physician makes a provisional diagnosis of acute pneumonia and orders relevant hematological as well as bacteriological investigations. He decides to introduce antibiotic therapy.

a) In case he selects an antibiotic that can be given orally as well as by i.m or i.v injection, which route of administration will be most appropriate in this case?

b) Should the pediatrician administer the antibiotic straight away or should he wait for the laboratory reports?

What type of oral dosage form generally yields the greatest amount of systemically available drug in the least amount of time? Why?

What effect does the oral administration of atropine sulfate have on the bioavailability of aspirin from an enteric-coated tablet?

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